Abstract
Studies show that some Trim family proteins are associated with tumorigenesis and cancer progression. Trim members are differently expressed in various cancers including lung cancer, hepatocellular carcinoma, colon cancer, stomach cancer and breast cancer. Trim proteins are found to be involved in tumor progess by modulating the expression of tumor associated genes via several signaling pathways such as p53 and NF-κB pathway. Members of Trim family can be used as oncogenes or anti-oncogenes in the biological processes such as tumor cell proliferation, cell differentiation, cell apoptosis and metastasis. Key words: Ubiquitination; Neoplasms; Genes, p53; Tripartite-motif protein
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