Trilostane, FAD286, and the role of aldosterone in the central regulation of blood pressure: focus on “Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats”

Abstract

in a previous issue of this journal, Elise Gomez-Sanchez et al. ([4][1]) presented unequivocal evidence that intracerebroventricular (ICV) infusion of the 3β-hydroxy steroid dehydrogenase inhibitor trilostane prevented the development of hypertension in response to high-salt intake in Dahl salt-