Abstract
We have recently shown in a preliminary study, that the retention in TLC, expressed as R(F) values, can be modelled in multiplicative trilinear way (solute × mobile phase × stationary phase), explaining almost all variance. Such possibility did not occur in the case of k or R(M) values. This paper is a continuation of investigation about this phenomenon. We perform here a trilinear decomposition of two datasets (normal-phase and RP) of 35 model compounds organized differently as in the previous study: solute × modifier × concentration. The resulted models explain 96.8% of whole variance on silica and 90.33% of RP18 variance. No strict correlation with any particular molecular descriptor was found, although the mean electrotopological state index (Ms) was fairly correlated with RP contributions. The results confirm definitively a general possibility to model TLC retention in a multiplicative manner and inspire for further research in this field.
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