Abstract
The effects of triiodothyronine and hydrocortisone individually and combined on Rana pipiens erythropoiesis have been studied in terms of their ability to stimulate hematocrit and 50Fe uptake into peripheral blood, bone marrow and spleen. The hormones individually stimulate erythropoiesis as indicated by increased isotope uptake into hemopoietic tissues and the hormones are approximately additive in terms of their ability to raise hematocrit and increase the % uptake of 50Fe into peripheral blood and spleen. These hormones have been shown to be elevated in frogs during the season when erythropoiesis is also high. Our data are consistent with the hypothesis that thyroid and adrenal cortical hormones are active in a general metabolic activity increase and thus stimulate erythropoiesis indirectly rather than by direct action on erythropoietic tissues.
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