Abstract
Given the inconsistent results on the prognostic significance of triglycerides (TGs), the purpose of the present study was to investigate the association of plasma TGs with left ventricular mass (LVM) in hypertensive patients. We studied 760 never treated, non diabetic, hypertensive patients. Τransthoracic echocardiography was performed and LVMI was calculated according to the Devereux formula, adjusted to body surface area. Triglycerides were associated with LVMI after adjustment for age, gender, systolic blood pressure (SBP), smoking and fasting glucose (b = 0.08, p = 0.009). This relationship remained significant even after adjustment for BMI, LDL-C and ApoB/ApoA1 ratio (b = 0.07, p = 0.04). Gender-stratified analysis indicated that TGs were related to LVMI in men (p = 0.001) but not in women (p = NS). In addition, TGs were related with LV hypertrophy (LVH) in men, increasing the odds by 7% to present LVMI over 115 g/m2 (OR = 1.07 per 10 mg/dl increase in TGs, p = 0.01). In conclusion, TGs are associated with LVMI in hypertensive patients, independently of other risk factors, including LDL-C. Given the prognostic significance of LVH, it might be suggested that TGs may serve as a useful marker for indentifying hypertensive patients at high risk. The gender discrepancy may suggest a possible gender-specific modulatory effect of TGs on LV structure.
Highlights
Given the inconsistent results on the prognostic significance of triglycerides (TGs), the purpose of the present study was to investigate the association of plasma TGs with left ventricular mass (LVM) in hypertensive patients
Systolic blood pressure (SBP) did not differ between the two genders (162 ± 14 vs 161 ± 14 mmHg, p = NS) but diastolic blood pressure (DBP) was slightly higher in men compared to women (104 ± 7 vs 102 ± 7 mmHg, p = 0.004)
We demonstrated a strong relationship of left ventricular mass index (LVMI) with plasma TGs in hypertensive patients, independently of other cardiometabolic risk factors including plasma low-density lipoprotein cholesterol (LDL-C)
Summary
Given the inconsistent results on the prognostic significance of triglycerides (TGs), the purpose of the present study was to investigate the association of plasma TGs with left ventricular mass (LVM) in hypertensive patients. Triglycerides were associated with LVMI after adjustment for age, gender, systolic blood pressure (SBP), smoking and fasting glucose (b = 0.08, p = 0.009) This relationship remained significant even after adjustment for BMI, LDL-C and ApoB/ApoA1 ratio (b = 0.07, p = 0.04). High levels of plasma TGs may explain part of the residual cardiovascular risk in statin-treated patients, including hypertensive patients, with optimal LDL-C levels[4]. Given the prognostic significance of LVH and the limited data on the role of plasma TGs in LV structure of hypertensive patients, we sought to investigate the association of LVM with plasma TGs in never treated hypertensive male and female patients
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