Triglyceride-Glucose Index Is Not Associated With Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank.

Lijie Wang,Fuzhong Xue,Jiqing Li,Xiaolu Chen,Shucheng Si,Yunxia Li,Wangang Ren

doi:10.3389/fonc.2021.774937

Lijie Wang, Fuzhong Xue + Show 5 more

Open Access

https://doi.org/10.3389/fonc.2021.774937

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Abstract

BackgroundThe triglyceride-glucose (TyG) index is a practical substitute measure for insulin resistance (IR). The relationship between IR and lung cancer has been examined in previous studies; however, the findings have been controversial. In addition, previous studies had small sample sizes. Thus, we systematically examined the association between IR and lung cancer risk based on the UK Biobank with IR measured by the TyG index and further examined the interactions and joint effects for lung cancer.MethodsA total of 324,334 individuals free from any type of cancer at recruitment from the UK Biobank prospective cohort were included. The participants were predominantly between 40 and 70 years old. After adjusting for relevant confounders, multivariable Cox regression models were constructed to examine the relationship between the TyG index and the risk of lung cancer. We also checked the interactions and joint effects using a polygenic risk score (PRS) for lung cancer.ResultsDuring a median follow-up of 9 years, 1,593 individuals were diagnosed with lung cancer. No association was found between the TyG index and lung cancer risk after multivariate Cox regression analysis adjusted for risk factors (hazard ratio: 0.91; 95% confidence interval: 0.64–1.18). No interaction or joint effects for genetic risk and the TyG index were observed.ConclusionThe TyG index was not associated with the risk of lung cancer. Our results provide limited evidence that IR is not correlated with the risk of lung cancer.

Highlights

Lung cancer is one of the most commonly diagnosed cancers causing many deaths each year [1]
There was no evidence of an elevated risk of lung cancer linked to the TyG index in Model 1 (HR: 0.895, 95% confidence interval (CI): 0.644–1.145, P = 0.385) after adjusting for age, sex, region, Townsend deprivation score, smoking status, alcohol intake frequency, Body mass index (BMI), waist-hip ratio (WHR), and hypertension
Similar estimates were obtained when fasting time, total cholesterol (TC), low-density lipoprotein cholesterol (LDL)-C, highdensity lipoprotein cholesterol (HDL)-C, and glycated hemoglobin (HbA1c) were included in Model 2 (HR: 0.911, 95% CI: 0.640– 1.182, P = 0.499) (Table 2)

Summary

Introduction

Lung cancer is one of the most commonly diagnosed cancers causing many deaths each year (representing approximately one in 10 cancers diagnosed and one in five deaths in 2020) [1]. Some studies have shown that the TyG index plays an important role as a potential risk factor for some diseases, such as metabolic syndrome [9], acute pancreatitis [10], cardiocerebrovascular diseases [11], and cancers of the digestive system [12]. Genetic susceptibility alleles could explain approximately 12% of heritability for lung cancer [18], and more than 50 genetic susceptibility loci have been identified in different ethnic groups [19], no work has been done to investigate the joint effects or interactions between the TyG index and the genetic susceptibility for lung cancer. We systematically examined the association between IR and lung cancer risk based on the UK Biobank with IR measured by the TyG index and further examined the interactions and joint effects for lung cancer

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