Triglyceride Level Is an Independent Risk Factor in First-Attacked Neuromyelitis Optica Spectrum Disorders Patients.

Kaimin Wu,Yanjie Jia,Qianyi He,Lijun Jing,Yaobing Yao,Yanfei Li,Junfang Teng,LuLu Wen,Ranran Duan

doi:10.3389/fneur.2019.01230

Kaimin Wu, Yanjie Jia + Show 7 more

Open Access

https://doi.org/10.3389/fneur.2019.01230

Copy DOI

Abstract

Objective: To investigate prospective associations between triglyceride (TG) level and prognosis of first-attacked patients with neuromyelitis optica spectrum disorders (NMOSD).Methods: This retrospective study included 196 patients newly diagnosed with NMOSD from June 2014 to December 2018. Data of clinical parameters, including age of onset, sex, BMI, blood lipid levels, anti-aquaporin-4 status, serum glucose level, therapy regimens, comorbidities, initial Expanded Disability Status Scale (EDSS), relapses, and outcomes were collected. We used logistic regression models to examine the associations among relevant clinical factors and outcomes, and statistical analyses were performed using the SPSS 23.0 software.Results: Compared with the high TG group, residual EDSS was relatively lower in the normal TG group (median 1.0 vs. 2.0, P = 0.002). In the univariate analysis, TG level was positively correlated with outcomes (OR 1.75, 95% CI 1.18–2.60, P = 0.005) and relapses (OR 1.57, 95% CI 1.07–2.31, P = 0.02). Our stratified analysis suggested that patients with normal BMI (OR 4.90, 95% CI 2.10–11.44, P = 0.001) were closely correlated with poor recovery owing to increased TG level. In the multivariate analysis, a statistically significant association still existed between TG level and outcomes (OR 3.44, 95% CI 1.02–11.64; P = 0.040) after adjusting for various variables.Conclusions: In first-attacked NMOSD patients, TG level was positively associated with poor recovery. Early monitoring and treatment of elevated TG level in NMOSD patients are important.

Highlights

Neuromyelitis optica spectrum disorders (NMOSD) is a type of autoimmune demyelinating disease that results in inflammatory lesions in the optic nerves, spinal cord, and other areas of the central nerve system (CNS) [1]
TG level was positively correlated with outcomes and relapses
Our stratified analysis suggested that patients with normal BMI were closely correlated with poor recovery owing to increased TG level

Summary

Introduction

Neuromyelitis optica spectrum disorders (NMOSD) is a type of autoimmune demyelinating disease that results in inflammatory lesions in the optic nerves, spinal cord, and other areas of the central nerve system (CNS) [1]. NMOSD is a rare disorder, it can cause serious disability partly because of high recurrence risk and progressive disability [2]. 80% NMO cases are seropositive for aquaporin-4 IgG [3], and myelin oligodendrocyte glycoprotein IgG is a highly specific diagnostic marker for NMOSD [4]. Besides these autoantibodies, many other factors, such as vitamin D level [5], hormone level [6], gastrointestinal infection [7], pregnancy [8], and diet [9], are involved in the pathological process of NMOSD. Another research suggested that high TG level increases the probability of recurrence of MS [14]

Methods

Results

Conclusion