Abstract
Background Triglyceride/high-density lipoprotein cholesterol (TG/HDL-c) ratio varies with vascular and other metabolic diseases. However, its role in acute type B aortic dissection is not well understood. In the current study, we evaluated the relationship between TG/HDL-c ratio and in-hospital mortality in type B aortic dissection. Methods We performed a retrospective analysis of consecutive patients between January 2015 and December 2018, by targeting dependent (TG/HDL-c ratio) and independent (in-hospital mortality) variables. TG/HDL-c ratio was determined as a division of TG levels by HDL-c levels. Results Of 523 patients in the study, we found a mean age of 55.00 ± 11.74 years, 15.68% of them being female. A fully-adjusted model revealed a positive relationship between TG/HDL-c ratio and in-hospital mortality in acute type B aortic dissection after adjusting confounders (OR = 2.08, 95% CI 1.32 to 3.27). This relationship was also nonlinear, with a point of 2.05. OR values (and confidence intervals) for the right (>2.05) and left (≤2.05) sides of the inflection point were 1.0 (0.580-1.26, P = 0.983) and 3.17 (1.54-6.57, P = 0.001), respectively. Conclusions The TG/HDL-c ratio and in-hospital mortality in type B AAD have a nonlinear relationship among Chinese population. This ratio increased in-hospital mortality when it is less than 2.05.
Highlights
Acute aortic dissection (AAD) is a rare, life-threatening condition associated with high morbidity and mortality rates [1, 2]
Studies have reported that medical treatment has been accepted as standard management for type B AAD, its 5-year total survival rate stands at 60% [6]
We aimed to evaluate the relationship between TG/high-density lipoprotein cholesterol (HDL-c) ratio and inhospital mortality in patients with type B AAD
Summary
Acute aortic dissection (AAD) is a rare, life-threatening condition associated with high morbidity and mortality rates [1, 2]. Studies have reported that medical treatment has been accepted as standard management for type B AAD, its 5-year total survival rate stands at 60% [6]. It is, urgent to investigate the risk factors of type B AAD mortality and develop an effective intervention. A fully-adjusted model revealed a positive relationship between TG/HDL-c ratio and in-hospital mortality in acute type B aortic dissection after adjusting confounders (OR = 2:08, 95% CI 1.32 to 3.27). This relationship was nonlinear, with a point of 2.05. This ratio increased in-hospital mortality when it is less than 2.05
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