Abstract
Background: Insulin resistance (IR) is a significant risk factor for cardiovascular disease (CVD). In this study, the association of the triglyceride glucose (TyG) index, a simple surrogate marker of IR, with arterial stiffness and 10-year CVD risk was evaluated.Methods: A total of 13,706 participants were enrolled. Anthropometric and cardiovascular risk factors were determined in all participants, while serum insulin levels were only measured in 955 participants. Arterial stiffness was measured through brachial-ankle pulse wave velocity (baPWV), and 10-year CVD risk was evaluated using the Framingham risk score.Results: All participants were classified into four groups according to the quartile of the TyG index. BaPWV and the percentage of participants in the 10-year CVD risk categories significantly increased with increasing quartiles of the TyG index. Logistic regression analysis showed that the TyG index was independently associated with a high baPWV and 10-year CVD risk after adjusting for traditional CVD risk factors. The area under the receiver operating characteristics curve (AUROC) of the TyG index for predicting a high baPWV was 0.708 (95%CI 0.693–0.722, P < 0.001) in women, higher than that in men. However, the association of the homeostatic model assessment of IR (HOMA-IR) with a high baPWV and the 10-year CVD risk was absent when adjusting for multiple risk factors in 955 participants.Conclusions: The TyG index is independently associated with arterial stiffness and 10-year CVD risk.
Highlights
Cardiovascular disease (CVD) is a leading cause of death among middle-aged and elderly individuals in both developing and developed countries [1]
Metabolic parameters, including BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), Pulse pressure (PP), fasting plasma glucose (FBG), hemoglobin A1c (HbA1c) total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C), and uric acid, increased, and the level of high-density lipoprotein cholesterol (HDL-C) decreased in proportion to the TyG index quartiles
Our results showed that the association of homeostatic model assessment of Insulin resistance (IR) (HOMA-IR) with high brachial-ankle pulse wave velocity (baPWV) and 10-year CVD risk was absent after adjusting for multiple risk factors
Summary
Cardiovascular disease (CVD) is a leading cause of death among middle-aged and elderly individuals in both developing and developed countries [1]. Some recent studies have shown that the TyG index is correlated with metabolic diseases but is associated with CVD [8, 9]. We investigated the association of the TyG index with arterial stiffness in Chinese adults using baPWV and Framingham risk score, a widely used metric for estimating the global risk of a 10-year CVD event. Insulin resistance (IR) is a significant risk factor for cardiovascular disease (CVD). The association of the triglyceride glucose (TyG) index, a simple surrogate marker of IR, with arterial stiffness and 10-year CVD risk was evaluated
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