Abstract
To identify triggering factors for the next inflammatory episode of recurrent acute anterior uveitis (RAAU), a 1:1 case–control study was conducted. We interviewed RAAU patients with recent acute anterior uveitis attack and quiescent controls for their information during a previous month using Srithanya Stress Test (ST-5) and questionnaires about potential triggering factors. Asymptomatic controls were matched for age (± 5 years), sex, and HLA-B27. There were 39 pairs of cases and controls. Patients who recently experienced a uveitis attack demonstrated higher mean ST-5 scores (3.7 ± 2.9 vs 0.7 ± 1.1) and shorter sleep time (6.3 ± 1.4 vs 7.4 ± 0.7 h per day) compared with their controls. In the multivariate conditional logistic regression analysis, ST-5 score ≥ 3 (OR 9.07, 95% CI 1.14–72.16, p = 0.037) and sleep time < 7 h per day (OR 12.12, 95% CI 1.37–107.17, p = 0.025) were more likely to trigger a uveitis attack in RAAU accounted for patients’ age, sex, HLA- B27 positivity, and presence of concurrent anti-inflammatory drugs for co-existing diseases. Other suspected triggering factors were not found to have any significant association. In short, stress and inadequate sleep may lead to the future episode of acute anterior uveitis in RAAU. Both physical and emotional stress management should be advised to RAAU patients to minimize recurrences and further complications.
Highlights
To identify triggering factors for the inflammatory episode of recurrent acute anterior uveitis (RAAU), a 1:1 case–control study was conducted
Hereby, conducted a matched case–control study to identify the possible triggering factors associated with a recent attack of uveitis in patients with RAAU in comparison with those in quiescence stage of the disease using in person or telephone interview questionnaires regarding stress, sleep time, life events, alcohol consumptions, smoking, exercise time, financial problems and joint pain
We reported mean with standard deviation (SD) or median with minimal-maximal range for continuous data and frequency with percentage for categorical data
Summary
To identify triggering factors for the inflammatory episode of recurrent acute anterior uveitis (RAAU), a 1:1 case–control study was conducted. We interviewed RAAU patients with recent acute anterior uveitis attack and quiescent controls for their information during a previous month using Srithanya Stress Test (ST-5) and questionnaires about potential triggering factors. Stress and inadequate sleep may lead to the future episode of acute anterior uveitis in RAAU Both physical and emotional stress management should be advised to RAAU patients to minimize recurrences and further complications. Hereby, conducted a matched case–control study to identify the possible triggering factors associated with a recent attack of uveitis in patients with RAAU in comparison with those in quiescence stage of the disease using in person or telephone interview questionnaires regarding stress, sleep time, life events, alcohol consumptions, smoking, exercise time, financial problems and joint pain
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