Abstract
Seizures are characterized by hypersynchronous neuronal discharges, and desynchronizing stimuli abort and sometimes prevent seizures. The most direct but invasive method has been the application of electrical cortical stimulation at seizure onset. This successful termination of seizures has formed the basis for translational research involving implantable seizure detection and neurostimulation devices. The pioneering work of Moruzzi and Magoun in 19491 demonstrated that stimulation of the ascending reticular activating system (ARAS) can have a desynchronizing effect on cortical rhythms. This system not only projects widely throughout cortex, but also receives collateral input from all sensory systems.
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