Abstract
Primary and secondary enolizable carboxylic acids and lithium carboxylates were successfully transformed into the corresponding trifluoromethylketones in a simple one-pot procedure via a) deprotonation to the enediolate with LDA, b) addition of F3CCO2Et, and c) decarboxylation through acidic quenching. This method could also be applied to the preparation of pentafluoroethyl and chlorodifluoromethyl ketones.
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