Abstract
Triethyllead (PbEt 3) was administered to young rats at the time of myelination onset (group A) and/or about the time of maximal rate of myelin deposition in the forebrain (group B). In both groups, the intoxication resulted in a pronounced growth retardation of the forebrain. The synthesis of forebrain lipids was inhibited more in group A; however, the deposition of myelin sheath was retarded to a greater extent in group B. Only in the case of cerebrosides was a correlation between the lipid synthesis and the myelin deposition observed. The forebrain myelin isolated from the intoxicated animals was depleted for sulphatides, albeit no changes in the concentration of other myelin lipids were observed whatsoever.
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