Abstract
Triethanolamine was found to be an efficient catalyst for the synthesis of new 1H-pyrazolo[1,2-a]pyridazine-5,8-diones by a one-pot reaction of maleic hydrazide, with aromatic aldehydes and malononitrile in H2O under ultrasonic irradiation. The advantages of this method are the use of an inexpensive and readily available catalyst, easy workup, improved yields, and the use of H2O as a green solvent. To assess their antibacterial activity, all the synthesized compounds were dissolved in DMSO and subjected to biological evaluation using the disc diffusion method against 3 Gram positive and 3 Gram negative bacteria.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.