Abstract
The compounds that are called tricyclic antidepressants (doxepin hydrochloride, amitriptyline hydrochloride, imipramine hydrochloride, trimipramine maleate, nortriptyline hydrochloride, protriptyline hydrochloride, and desipramine hydrochloride) were discovered to have antidepressant efficacy beginning in the 1950s, shortly after chlorpromazine hydrochloride was found to be effective for treating psychoses. Researchers took compounds from the shelves of pharmaceutical houses that were similar to chlorpromazine in structure and pharmacology to look for other agents for the treatment of psychoses. The antihistamine imipramine was the first drug in this group to be shown to be effective as an antidepressant after it failed to demonstrate antipsychotic efficacy. 1 Soon after the tricyclic antidepressants became available for use clinically, it was learned that these compounds were potent inhibitors of the presynaptic uptake of norepinephrine and serotonin. These early findings represent some of the cornerstones of the biogenic amine hypothesis of mood disorders. More recently, we have learned about the effects
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.