Abstract
Abnormalities of thyroid function have been associated with affective disorders, and treatment with thyroid hormones or drugs that alter thyroid hormone levels can change the course of an affective disorder. Therefore, we investigated the possibility that mood-altering effects of tricyclic antidepressants would be mediated by alterations in thyroid hormone (T 3 and T 4) levels. In a group of 11 patients with affective disorders, tricyclic antidepressants did not alter serum T 3 and T 4 levels. We conclude that the mood-altering potency of tricyclic antidepressants, and particularly their potency to induce rapid mood cycles, is not due to changes in total T 3 and T 4 serum levels.
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