Abstract
Triclosan (TCS) is a widespread environmental endocrine-disrupting chemical. Animal and in vitro studies suggested that triclosan may affect homesostasis of sex and thyroid hormones and impact on reproduction. Due to limited data derived from human epidemiological studies, this study was performed to examine the association between urinary concentration of triclosan and in vitro reproductive outcomes (methaphase II (MII) oocyte yield, top quality embryo, fertilization rate, implantation rate, and clinical pregnancy) among women from infertility clinic. The study participants were enrolled in an Infertility Center in Poland. A total of 450 women aged 25–45 (n = 674 IVF cycles) provided urine samples. The urinary concentrations of triclosan were evaluated using validated gas chromatography ion-tap mass spectrometry method. Clinical outcomes of IVF treatment were abstracted from patients electronic chart records. Triclosan was detected in urine of 82% of women with geometric mean 2.56 ± 6.13 ng/mL. Urinary concentrations of triclosan were associated with decrease implantation rate (p = 0.03). There were no association between other examined IVF outcomes: MII oocytes, embryo quality, fertilization rate, and exposure to triclosan. As this is one of the first study on this topic, studies among larger and more diverse population are needed to confirm the results.
Highlights
Man-made, widespread, environmental chemicals which have been used widely for decades have the ability to disrupt hormonal homeostasis and affect human fertility
Environmental exposure to triclosan may occur via consumer products that contain TCS, and through water and/or food products contaminated with TCS (Weatherly and Gosse 2017)
The aim of the study was to investigate the effect of environmental exposure to triclosan and early reproductive outcomes (MII oocyte count, top quality embryo, fertilization rate, implantation rate, and clinical pregnancy)
Summary
Man-made, widespread, environmental chemicals which have been used widely for decades have the ability to disrupt hormonal homeostasis and affect human fertility. One of this chemicals is triclosan (TCS) used in personal care products such as soaps and toothpaste, household products, and pharmaceuticals as broad-spectrum antibacterial additives (Yuan et al 2015). Environmental exposure to triclosan may occur via consumer products that contain TCS, and through water and/or food products contaminated with TCS (Weatherly and Gosse 2017). During the first 4 days after exposure, between 24 and 83% of the consumed TCS is excreted, and after 8 days, excretion approaches baseline levels (Sandborgh-Englund et al 2006)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
