Abstract
Suitable conditions were established for the passive cellular transfer of protective immunity to the intestinal nematode, T. colubriformis, in guinea pigs. The most effective meseoteric lymph node cell populations were obtained 7 days after the second of two immunizing infections given 35 days apart. Transferred resistance varied directly with the dose of immune cells. Thus, 800 × 10 6 cells conferred the most solid protection, whereas 12 × 10 6 cells were ineffective. Challenge with 2000 infective larvae produced the maximum expression of resistance in cell recipients. The age of donors was more important than the age of recipients in this cell transfer system. Prepubertal guinea pigs had a limited capacity to generate immune lymphocytes which transferred protection. Protective immunity was measured with most sensitivity by worm counts made 14 days after cell transfer and challenge.
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