Trichloroisocyanuric Acid, A Swimming Pool Disinfectant: New Developments and Role in UV-Induced Skin Inflammation†.

Abstract

This article is a highlight of the paper by Snell etal. in the current issue of Photochemistry and Photobiology (Snell etal. Photochem. Photobiol. 2022). The authors utilized an organotypic human skin model and transgenic SKH-1 mice to determine the oxidative stress response induced by topical treatment of trichloroisocyanuric acid (TCIC), a common disinfectant used in swimming pool. Additionally, they determined molecular mechanisms associated with topical TCIC pretreatment followed by ultraviolet (UV) radiation exposure. This work provides the first example that cutaneous delivery of TCIC significantly increases UV-induced skin inflammation, suggesting a previously unidentified potential of TCIC. If translatable to human skin, these findings could be important for human skin health implications.