Abstract
Trichloroethylene (TCE) is widely used as an industrial degreasing agent, solvent and extraction agent. If TCE is absorbed into the body it can cause toxic effecs on the nervous system, liver, kidney, heart and skin. There appears to be genetic susceptibility to TCE. The common clinical manifestations of TCE toxicity include hepatitis and generalized severe dermatitis and skin eruptions, including erythema multiforme, Stevens–Johnson syndrome and toxic epidermal necrolysis. The pathogenesis of this TCE hypersensitivity syndrome is unknown. Its manifestation resembles a drug-induced hypersensitivity syndrome. Physicians managing patients presenting with severe skin eruptions associated with hepatitis mimicking drug-induced hypersensitivity syndrome should always obtain a careful occupational history to exclude TCE exposure.
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