Abstract
Administration of double-stranded synthetic polynucleotide, polyribosinic-polyribocytidylic acid [poly(I · C)] to animals sensitized once to Trichinella spiralis antigen + complete adjuvant (Difco's H37 Ra) did not affect induction or transfer of delayed hypersensitivity. Poly (I · C) did not enhance antibody production in animals sensitized only once when tested by passive cutaneous anaphylaxis (PCA). However, it appeared to enhance antibody production in hypersensitized animals. Several of the undiluted serum samples from hypersensitized animals treated with 3 mg of poly(I · C) were anaphylactogenic and inhibitory when tested by PCA, but not when serum samples were diluted 1:80. Possible reasons for these phenomena are discussed.
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