Tributyltin Hydride (Bu3SnH)

Abstract

The realization of compatibility of radical methods with a range of functional groups without further protection has led to an increased interest in the use of radicals in organic synthesis. Bu3SnH is a well-known radical reagent because of its relatively weak and nonionic bond interaction between tin and hydrogen that can be cleaved homolytically. [1] Thus it has been explored extensively in reductive cleavage, [2a] radical dehalogenation, deoxygenation [2b] and intramolecular radical cyclization [2c] as well as in the synthesis of various heterocyclic compounds, natural products and many pharmaceutically important drugs. [2d-j]