Abstract
Zebrafish has been established as a reliable biological model with important insertion in academy (morphologic, biochemical, and pathophysiological studies) and pharmaceutical industry (toxicology and drug development) due to its molecular complexity and similar systems biology that recapitulate those from other organisms. Considering the toxicological aspects, many efforts using zebrafish models are being done in order to elucidate the effects of endocrine disruptors, and some of them are focused on tributyltin (TBT) and its mechanism of action. TBT is an antifouling agent applied in ship’s hull that is constantly released into the water and absorbed by marine organisms, leading to bioaccumulation and biomagnification effects. Thus, several findings of malformations and changes in the normal biochemical and physiologic aspects of these marine animals have been related to TBT contamination. In the present review, we have compiled the most significant studies related to TBT effects in zebrafish, also taking into consideration the effects found in other study models.
Highlights
Zebrafish, Danio rerio, is a native teleost to the southeastern Himalayan region that has emerged as a reliable model for studying embryogenesis and regeneration, and disease
Zebrafish has a high fertility rate that is characterized by dozens of embryos per matching couple, which allow a significant number of genetic approaches, such as morpholino antisense oligonucleotide technology to knock down several genes, study their function, and generate new disease models [2]
Zebrafish is a reliable model for studying several diseases like cancer, obesity, and inflammation and has become a robust tool for assessing Endocrine-disrupting chemicals (EDCs) effects
Summary
Danio rerio, is a native teleost to the southeastern Himalayan region that has emerged as a reliable model for studying embryogenesis and regeneration, and disease. Zebrafish has a high fertility rate that is characterized by dozens of embryos per matching couple, which allow a significant number of genetic approaches, such as morpholino antisense oligonucleotide technology to knock down several genes, study their function, and generate new disease models [2]. Zebrafish has been used in the field of drug discovery with great success, since it can be used for target identification, pharmacokinetic/pharmacodynamic, and toxicology studies [3]. Due to its large and traditional use in the drug discovery field, the expertise of zebrafish model has been transferred to the analysis of endocrine disruptor effects
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