Abstract
The Waterhouse-Friderichsen Syndrome was first reported by Rupert Waterhouse exactly 100 years ago on March 4th, 1911. It is an acute infectious disease that generally progress to a lethal outcome despite the adoption of all available resources of an intensive therapy unit. We describe an illustrative case of meningococcal meningitis C. This report details the clinical, pathological and therapeutic features of a patient of 3 years and 4 months who had a fulminating evolution, despite adherence to updated recommendations for the treatment of pediatric septic shock. We stress the little change in clinical and pathological aspects of Waterhouse-Friderichsen Syndrome during the last 100 years, despite tremendous advances in therapy and technology of the pediatric intensive care.
Highlights
The Waterhouse-Friderichsen Syndrome was first reported by Rupert Waterhouse exactly 100 years ago on March 4th, 1911
Apesar dos inúmeros avanços alcançados pela medicina desde 1911, a evolução fatal da síndrome de Waterhouse-Friderichsen (SWF) foi compartilhada por ambos os pacientes pediátricos com um século de diferença
The Waterhouse-Friderichsen Syndrome: Report of three cases in adults with necropsy findings
Summary
Valor de referência 136 - 146 mEq/l 3,5-5,5 mEq/l 10 a 50 mg/dl 0,4 a 1,3 mg/dl mg/dl arterial: 3,0 a 13,2 mg/dl 8,6 - 10 mg/dl. 6 - 8 g/dl 3 - 5 g/l 1,5 - 3,5 g/dl Valor de referência 7,34 -7,44 75- 100 mmHg 35-45 mmHg 22-26 mEq/l 95 - 98 % Valor de referência 10,3-15.2 g% 4500 a 15.000/mm3 150.000 a 400.000/ mm[3]
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