Abstract
The present project aims to evaluate Tribulus terrestris (TT) extracts by addressing various possible mechanisms of action in order to see whether the use of TT supplements in diabetes and diabetes complications is justified. Diabetic rats were divided into three groups: diabetic control group, TT extract with low protodioscin content group (TT-LPC) and TT extract with high protodioscin content group (TT-HPC). After twelve weeks of treatment, fasting blood glucose, insulin, LH, FSH and testosterone levels were measured. Both TT preparations reduced elevated blood glucose level. Insulin and luteinizing hormone levels were not significantly different compared with the control group; however, the FSH and testosterone levels were significantly higher in the TT-HPC group compared with the diabetic control group. The testosterone level is correlated in part with the protodioscin concentration in extracts and is probably mediated through an FSH-linked pathway.
Highlights
In the first herbal drug (TT-1.2-17), the concentration of protodioscin was under the limit of quantification (
This product was used in the experimental determination as the Tribulus terrestris low protodioscin content extract (TT-LPC)
For this experiment we randomly selected an herbal drug with very low the influence of PRD on treatment outcome, starting from the that this protodioscin content andthe one with high protodioscin content, in assumption order to evaluate the compound could be partially responsible for the documented effects of influence of PRD on the treatment outcome, starting from the assumption that this
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Tribulus terrestris (TT) is one of the most controversial plants encountered in the literature. Several studies suggest that the administration of extracts obtained from the fruits could improve sexual performance, improve the symptoms of erectile dysfunction and increase libido in animals and/or humans [1,2]. There is the belief that the administration has no effects on the sexual parameters. These extracts could increase athletic performance, but the scientific results seem to be in contradiction [2,3]
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