Abstract
Tribromoisocyanuric Acid (TBCA) as a Mild and Metal Free Catalyst for the Acetylation and Formylation of Hydroxyl Groups under Solvent Free Conditions
Highlights
Protection-deprotectionsteps of active proticfunctional groups are frequently required in the synthesis of multifunctional compounds
Oformylation is an important process in organic synthesis, because the formate esters serve as a useful synthetic reagent and intermediate[1,2,3]
Acetylation of benzyl alcohol using acetic anhydride catalyzed by tribromoisocyanuric acid
Summary
Protection-deprotectionsteps of active proticfunctional groups are frequently required in the synthesis of multifunctional compounds. The protection of alcohols and phenols by the formation of ester is one of the most important and widely used transformations in organic chemistry. Among the various protecting groups which have reported for the hydroxyl function, the acetyl is the most common because of its ease of formation as well as mild conditions for deprotection. Acylation of alcohols with anhydrides is one of the most routinely used transformations in organic synthesis. A variety of procedures are routinely performed for the preparation of formyl derivatives including homogeneous or heterogeneous catalyst (16-22). There is a need for a mild, neutral and catalytically efficient alternative for the protection of hydroxyl groups as acetyl and formyl derivatives
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