Abstract
BackgroundA large number of studies have recently reported that, because of their significant biological and pharmacological properties, heterocyclic compounds and their derivatives have attracted a strong interest in medicinal chemistry. The triazole nucleus is one of the most important heterocycles which has a feature of natural products as well as medicinal agents. Heterocyclic nitrogen is abundantly present in most medicinal compounds. The derivatization of triazole ring is based on the phenomenon of bio-isosteres in which substituted the oxygen atom of oxadiazole nucleus with nitrogen triazole analogue.Main textThis review focuses on recent synthetic procedure of triazole moiety, which comprises of various pharmacological activities such as antimicrobial, anticonvulsant, anti-inflammatory, analgesic, antitubercular, anthelmintic, antioxidant, antimalarial, antiviral, etc..ConclusionThis review highlights the current status of triazole compounds as different multi-target pharmacological activities. From the literature survey, triazole is the most widely used compound in different potential activities.
Highlights
This review focuses on recent synthetic procedure of triazole moiety, which comprises of various pharmacological activities such as antimicrobial, anticonvulsant, anti-inflammatory, analgesic, antitubercular, anthelmintic, antioxidant, antimalarial, antiviral, etc
Fivemember heterocyclic nitrogen-containing compounds such as triazole are of great importance due to their wide range of biological applications such as anticonvulsant [6, 7], antimicrobial [8, 9], antiviral [10, 11], antitubercular
This review has presented comprehensive details of triazole analogues, potent compounds reported for particular pharmacological activity and the method or technique involved in evaluation process
Summary
Triazole Triazole is a five-member heterocyclic ring containing two carbon and three nitrogen atoms with molecular formula C2H3N3 [4]. Ma et al reported a novel series of 1,2,3-triazole-pyramidine hybrid derivatives and screened their cytotoxic potential towards several tumour cell lines Among these synthesized compounds, the compound 44a exhibited the potent and selective anti-proliferative activity with IC50 values in range between 1.42 and 6.52 μM. Wang et al reported a novel series of sulfanyl-triazole derivatives as an HIV-1 non-nucleoside reverse transcriptase inhibitor by using high throughput screening It exhibited significant activities against the selected resistant mutants. Thakkar et al reported new ten compounds containing 1,2,4-triazole and evaluated their in vitro antimalarial activity against P. falciparum strain All these synthesized derivatives were characterized by IR, 1H NMR, 13C NMR, mass spectroscopy, and elemental analysis. Abbreviations IC50: Half maximal inhibitory concentration; SAR: Structure–activity relationship; EC50: Median effective concentration required to induce a 50% effect; COX: Cyclooxygenase; MBC: Minimum bactericidal concentration; MIC: Minimum inhibitory concentration; PEG: Polyethylene glycol; PI: Plaque index; IR: Infrared; NMR: Nuclear magnetic resonance
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