Abstract
The synthesis of a new heterocyclic building block for unnatural peptide analogues is described, and examples of its application are demonstrated. The 1,3,5-triazine nucleus is readily derivatized to possess an amino and a carboxy terminus, and the third site can be used to incorporate a wide variety of functional groups into an oligomer. This third site can also serve as the point of attachment to a solid-phase resin, allowing convenient construction of macrocyclic pseudopeptides that should be useful as clefts for molecular recognition studies or models of β-strand conformation.
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