Triazine-Porphyrin-based aminal linked porous organic polymer as self-enhanced photo/enzyme synergistic antibacterial agent for wound healing

Abstract

Here, a series of heteroatom-rich porous organic polymers (POPs) with aminal-linkage were facilely synthesized via Schiff base polycondensation reaction between the triazine-Porphyrin based monomer bearing eight amino groups and low cost monomer containing a single aldehyde moiety (Ferrocene, imidazole, 4-bromomethylbenzaldehyde, p-hydroxybenzaldehyde and 3,5-dimethoxybenzaldehyde). The combination of photoactive triazine-Porphyrin with redox-active Ferrocene endowed the self-enhanced photothermal, photodynamic, as well as peroxidase-like activity with the special POP (TPF-POP), which could function as a smart collaborative antimicrobial antibacterial platform. Notably, in vitro experiments verified TPF-POP could not only effectively excite the generation of reactive oxygen species (ROS) from the ambient oxygen and low levels of hydrogen peroxide (H2O2), but also transform the light energy into local heat exerting photothermal effects, presenting an effective bacterial killing effect towards both the S. aureus and E. coli at a low concentration (200 μg/mL). In vivo animal experiments demonstrated the wound coverage of TPF-POP-treated mice with back wound infection model was significantly reduced to 9.53 % within 9 days. These results confirmed TPF-POP with concurrently photocatalytic and enzymatic activity featured broad application prospect for promoting the repairing of infected wound. The as-proposed methods are available for the low-cost preparation of POPs with specific functions.