Triazine as Antitumor : Synthesis of Novel Tiriazolo - and/ or Triazino -1,2,4-triazines as Anticancer Agent

Abstract

Novel series of fused 1,2,4 –triazin derevateives ( 3 and 4) were prepared via the cyclization of 5-(p-fiorobenzylidene)-3-(p-chlorophenyl)-2(amino)thiocarbonyl-1,2,4-triazine-6-one with acetic anhydriede and ethyl chloroacetate in the presence of fused sodium acetate under reflux. Triazino -1,2,4-triazine derevateives ( 5 ,6 and 7) were obtained from the reaction of 4 with acetic anhydried , p-chlorophenacyl bromide and aromatic aldhydes . The structure of the fused 1,2,4 –triazine were confirmed by IR ,1H-NMR ,13C-NMR MS and elemental analysis.