Abstract
The problem of the bacterial cystitis treatment continues to be relevant among the urologists all over the world due to its prevalence rate and the complexity in its treatment. The goal of research: to study experimentally the influence of synthetic glucocorticoidtriamcinоlon on the inflammatory mucosa of the urinary bladder. Material. The experimental study was conducted on the outbred white reproductive rats-females. The main group of the animals (40 rats) was exposed to simulation of the inflammatory mucosa of the urinary bladder. Triamcinоlon instillations (0.3 ml) were performed on 20 rats. In the other group of rats the triamcinоlon instillation was added with intramuscular injection of antibiotics. There were two compari-son groups of rats with the simulated inflammatory mucosa of the urinary bladder. The first (20 rats) re-ceived only intramuscular antibiotics injections and the second (20 rats) received no treatment. The con-trol group of animals (10 rats) received instillations of intact 0.9% NaCl. Methods. The bladder wall ultrastructure was analyzed by the method of transmission electronic microscopy. Rresults. According to the research data, decongestion of the swelling enchasing mass was observed after 5 days of triamcinоlon instillations both with antibiotics and without it in comparison with the inflammatory process without any treatment and with the antibiotics injections only. After 10 days this result in the main group was the same as in the control group. Infiltrating cells density in the main group after 7 days was obviously lower than in the comparison groups. The triamcinоlon injections induce neovasculogenesis and fibrogenesis, improve hemorheology in the vascular plexus of the urinary bladder mucosa. The results come up to a high level of statistical significance. Summary. The experimental data prove the safety of intravesical triamcialon instillation and its therapeutic effectiveness.
Highlights
The problem of the bacterial cystitis treatment continues to be relevant among the urologists all over the world due to its prevalence rate and the complexity in its treatment
The experimental study was conducted on the outbred white reproductive rats-females
In the other group of rats the triamcinоlon instillation was added with intramuscular injection of antibiotics
Summary
Проведено экспериментальное исследование на 90 беспородных белых половозрелых крысах-самках массой 200–250 г. В гистологических препаратах мочевого пузыря у крыс на 3-и сут после введения триамциналона определялась морфологическая картина, соответствующая воспалению. При морфометрическом исследовании слизистой оболочки мочевого пузыря у крыс на 3-и сут после введения триамциналона, по сравнению с контрольной группой и группой сравнения, не обнаружено статистически значимых различий по объемной плотности эпителия, соединительной и мышечных тканей в собственной пластинке слизистой, подслизистой и мышечной оболочке мочевого пузыря При морфометрическом исследовании слизистой оболочки мочевого пузыря на 7-е сут введения триамциналона, по сравнению с контрольной группой и на фоне введения антибиотика, обнаружено статистически значимое (р < 0,05) уменьшение плотности клеточного инфильтрата, отека и удельного объема коллагеновых волокон На 10-е сут в гистологических препаратах основной группы животных, по сравнению с аналогичными сроками в двух других группах исследования, в слизистой и подслизистой оболочках мочевого пузыря происходила регенерация эпителия, а также нормализовались сосудистые и клеточные реакции. (ТАЦ + АБ), ния (АБ), па (ТАЦ + АБ), ния (без лече- па (ТАЦ + АБ), ния (АБ), па (ТАЦ + АБ), 7-е сут ния), 10-е сут 10-е сут
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