Trial-Specific Feature Performance on Single-Channel Auditory Mismatch Negativity Detection

Abstract

Successful detection of uncommon events is vital in the survival of an organism. Specifically, the study of neuro-sensory detection lends itself widely to understanding the human brain. Mismatch Negativity (MMN) is an important Event-Related Potential (ERP) response to an oddball stimulus which is preceded by repeated homogeneous stimulation. MMN is associated with perceptual learning and medical diagnostics among other applications. Currently, MMN detection relies on visual inspection of ERPs by skilled clinicians which makes for a costly, slow and subjective tool. In this paper, we use MMN to quantify the discriminative abilities of healthy or diagnosed subjects. We introduce a novel algorithmic method to extract and select important trial-specific features for discriminating standard from deviant responses. We utilize machine learning and classification approaches to evaluate our novel model using single-subject trial data while minimizing the number of necessary selection features provided by statistical test parameters and Genetic Algorithm (GA). In this work, a large variety of methods with 27 subjects, hundreds of trials and electrode counts compete for the definitive discrimination of MMN events. Our model requires only one EEG channel, a single subject and as low as five deviant tones. The results show statistically significant detection improvement over the traditional methods while maximizing resource economy.