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Abstract
Timolol was compared with placebo in a double-blind randomized crossover study in 54 women affected by menopausal symptoms. The results were assessed with Blatt's Menopausal Index, modified so that it could be subdivided into vasomotor, psychogenic, and sexual symptoms. There was significant relief of vasomotor symptoms with both timolol and placebo by week 4, but no further significant differences during the next four weeks. Other symptoms were relieved to a lesser or insignificant extent. This study demonstrates the existence of noticeable, if time limited, placebo effect on selected menopausal symptoms.
Published Version
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