Abstract
Robinson LR, Czerniecki JM, Ehde DM, Edwards WT, Judish DA, Goldberg ML, Campbell KM, Smith DG, Jensen MP. Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study. Arch Phys Med Rehabil 2004;85:1–6. Objective To evaluate whether amitriptyline is more effective than placebo in improving phantom limb pain or residual limb pain. Design Randomized controlled trial of amitriptyline for 6 weeks. Setting University hospital. Participants Thirty-nine persons with amputation-related pain lasting more than 6 months. Intervention Six-week trial of amitriptyline (titrated up to 125mg/d) or an active placebo (benztropine mesylate). Main outcome measures Analyses were conducted to examine whether there was a medication group effect on the primary outcomes (average pain intensity) and secondary outcome measures (disability, satisfaction with life, handicap). Results No significant differences were found between the treatment groups in outcome variables when controlling for initial pain scores. Conclusions Our findings do not support the use of amitriptyline in the treatment of postamputation pain.
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