Abstract
2,3,5-Tris-ethyleneiminobenzoquinone (1,4), a strong alkylating mutagen, was used in vivo to induce chromosomal damage in bone-marrow cells of the following species: Chinese and Syrian hamster, mouse, rat and guinea pig. Four different single doses between 0.031 and 0.25 mg/kg were tested. In addition, some pilot studies were performed on Rhesus monkeys. The preparations were scored for three types of aberration: micronuclei in erythrocytes (Jolly bodies), micronuclei in white cells and nuclei in lysis. A dose-dependent increase in the incidence of the three types of aberration was found in all six species with no major interspecific differences in the total percentages of nuclear anomalies. The results are in good correlation with those obtained with the cytogenetic method in Chinese hamster bone marrow. The micronucleus test appears to be a useful method offering the advantages of technical simplicity and applicability to a wide range of test mammals, irrespective of a cytologically favorable karyotype.
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