Abstract
There has been increasing concern in the kidney transplant community about the declining use of expanded criteria donors (ECD) despite improvement in survival and quality of life. The recent introduction of the Kidney Donor Profile Index (KDPI), which provides a more granular characterization of donor quality, was expected to increase utilization of marginal kidneys and decrease the discard rates. However, trends and practice patterns of ECD kidney utilization on a national level based on donor organ quality as per KDPI are not well known. We, therefore, performed a trend analysis of all ECD recipients in the United Network for Organ Sharing (UNOS) registry between 2002 and 2012, after calculating the corresponding KDPI, to enable understanding the trends of usage and outcomes based on the KDPI characterization. High-risk recipient characteristics (diabetes, body mass index ≥30 kg/m2, hypertension, and age ≥60 years) increased over the period of the study (trend test p<0.001 for all). The proportion of ECD transplants increased from 18% in 2003 to a peak of 20.4% in 2008 and then declined thereafter to 17.3% in 2012. Using the KDPI >85% definition, the proportion increased from 9.4% in 2003 to a peak of 12.1% in 2008 and declined to 9.7% in 2012. Overall, although this represents a significant utilization of kidneys with KDPI >85% over time (p<0.001), recent years have seen a decline in usage, probably related to regulations imposed by Centers for Medicare & Medicaid Services (CMS).When comparing the hazards of graft failure by KDPI, ECD kidneys with KDPI >85% have a slightly lower risk of graft failure compared to standard criteria donor (SCD) kidneys with KDPI >85%, with a hazard ratio (HR) of 0.95, a confidence interval (CI) of 0.94-0.96, and statistical significance of p<0.001. This indicates that some SCD kidneys may actually have a lower estimated quality, with a higher Kidney Donor Risk Index (KDRI), than some ECDs. The incidence of delayed graft function (DGF) in ECD recipients has significantly decreased over time from 35.2% in 2003 to 29.6% in 2011 (p=0.007), probably related to better understanding of the donor risk profile along with increased use of hypothermic machine perfusion and pretransplant biopsy to aid in optimal allograft selection.The recent decline in transplantation of KDPI >85% kidneys probably reflects risk-averse transplant center behavior. Whether discard of discordant SCD kidneys with KDPI >85% has contributed to this decline remains to be studied.
Highlights
The existing donor supply of kidney allografts is unable to meet the growing demand of patients awaiting transplantation
This represents a significant utilization of kidneys with Kidney Donor Profile Index (KDPI) >85% over time (p
A policy enabling the use of expanded criteria donors (ECD) kidneys was implemented in November 2000 [2] with the concept that, there would be a 70% greater likelihood of graft loss when compared to standard criteria donor (SCD) kidneys, the survival benefit compared to dialysis would still be significant [3]
Summary
The existing donor supply of kidney allografts is unable to meet the growing demand of patients awaiting transplantation. Survival and improvement in quality of life with ECD kidney transplantation has been demonstrated previously [4,5,6]; the patterns of ECD use on a national level are not well delineated, and there is increasing concern in the transplant community that ECD utilization practices are declining, thereby limiting access to life-saving transplants among viable candidates [7]. In 2012 the Organ Procurement and Transplantation Network (OPTN) introduced KDPI, which compiles 10 donor factors (instead of four in the ECD definition) that are independently associated with all-cause allograft survival associated with the use of that particular organ. KDPI was the basis of the new allocation policy introduced toward the end of 2014 to increase utilization of marginal kidneys and decrease the discard rates that would be expected using the older ECD classification [8]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
