Abstract
We investigated changes to transfusion practices over time in paediatric liver transplant centre and evaluated the effect of transfusion practice to mortality. A pilot retrospective study included two cohorts each with 101 sequential paediatric LT recipients: an Early group (1994-1998) and a Recent group (2009-2013). Demographic characteristics and data on the intraoperative transfusion of red blood cells (RBC), fresh-frozen plasma (FFP), platelets and cryoprecipitate were collected. Postoperative laboratory results were also obtained, together with donor and data regarding 1- and 5-year survival. Appropriate intergroup comparisons, univariate and multivariate analysis were made and P≤0·05 was considered statistically significant. There were no significant group differences in demographic data (except patient height). Despite the fact that median total blood loss did not differ between groups (111ml/kg in both groups), the Early group had greater levels of intraoperative RBC transfusion (75 vs. 59ml/kg, respectively, P=0·04) and less use of FFP (53 vs. 62ml/kg, respectively, P=0·01). Overall we noted a lower 1- and 5-year survival in the Early group (88·2% vs. 96%, P=0·04 and 82·4% vs. 89·1%, P=0·01, respectively). Univariate, but not multivariate regression analyses demonstrated that higher PELD score, RBC and FFP transfusion, and inclusion in the Early group were contributing factors to 1-year higher mortality. This retrospective analysis of blood loss and replacement in paediatric LT patients demonstrates that the majority of our patients suffer major haemorrhage and require large-volume RBC and FFP replacements. In our pilot study, large volume of RBC and FFP replacement did not contribute to mortality. Paediatric LT involves a number of multidisciplinary teams. Thus, all care-related factors and combinations thereof that may contribute to outcome and should be evaluated in the future.
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