Trends in the Prevalences of Selected Birth Defects in Korea (2008⁻2014).

Jung-Keun Ko,Hwan-Cheol Kim,Dirga Lamichhane,Jong-Han Leem

doi:10.3390/ijerph15050923

Jung-Keun Ko, Hwan-Cheol Kim + Show 2 more

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https://doi.org/10.3390/ijerph15050923

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Abstract

Little information is available on the prevalences of birth defects in Korea. The aims of this study were to estimate recent prevalences of selected birth defects and to analyze the prevalence trends of these defects during the period from 2008 to 2014. Prevalences were calculated for 69 major birth defects using health insurance claim data obtained from the Korea National Health Insurance Service (NHIS). Prevalence rate ratios were calculated using Poisson regression to analyze trends over the 7-year study period. The overall prevalence of a major birth defect was 446.3 per 10,000 births (95% CI: 444.0–448.6); 470.9 per 10,000 births (95% CI: 467.6–474.2) for males and 420.2 per 10,000 births (95% CI: 417–423.4) for females. The prevalence rates of the most common birth defects over the study period were; septal defect (138.2 per 10,000; 95% CI: 136.9–139.5), congenital hip dislocation (652 per 10,000; 95% CI: 64.1–65.9), and ventricular septal defect (62.62 per 10,000; 95% CI: 61.7–63.5). During the study period, a significant increase in the prevalence of a major birth defect was observed with a prevalence rate ratio (PRR) of 1.091. The strongest trend was observed for renal dysplasia, which had a PRR of 1.275 (95% CI: 1.211–1.343), and upward trends were observed for urogenital anomalies, such as, renal agenesis (PRR 1.102, 95% CI: 1.067–1.138), undescended testis (PRR 1.082, 95% CI: 1.072–1.093) and hypospadias (PRR 1.067, 95% CI: 1.044–1.090). This study shows an overall increase in the prevalences of birth defects, including hypospadias and undescended testis, which are known to be associated with endocrine factors. In the future, standardized birth defect registries should be established to enable these trends to be monitored.

Highlights

Worldwide, about 3–6% of infants are born with a major defect [1], and 11.3% of infant mortalities occurring within four weeks of birth are due to congenital malformations [2]
The strongest trend was observed for renal dysplasia, which had a prevalence rate ratio (PRR) of 1.275, and upward trends were observed for urogenital anomalies, such as, renal agenesis (PRR 1.102, 95% CI: 1.067–1.138), undescended testis (PRR 1.082, 95% CI: 1.072–1.093) and hypospadias (PRR 1.067, 95% CI: 1.044–1.090)
This study shows an overall increase in the prevalences of birth defects, including hypospadias and undescended testis, which are known to be associated with endocrine factors

Summary

Introduction

About 3–6% of infants are born with a major defect [1], and 11.3% of infant mortalities occurring within four weeks of birth are due to congenital malformations [2]. Surveillance of Congenital Anomalies (EUROCAT) reported that the prevalence of major congenital anomalies in 2003–2007 was 239 per 10,000 births, of which 80% were delivered, 17.6% were terminated by induced abortion, 2.5% died after birth, and 2% were stillbirths [3]. During the period 1978–2005, the prevalence of major birth defects was estimated at 3% in Atlanta, GA, USA [4]. In Korea, the prevalence of 27 selected birth defects in 2002 was 57.8 per 10,000 live births and 750.6 per 10,000 stillbirths [5]. The prevalence of 69 major specific birth defects, as monitored by the National Birth. Based on data obtained from 5 hospitals in Seoul and Gyeonggi Province in 2009–2010, the prevalence of the specific birth defects considered by EUROCAT was 348.7 per 10,000 [7]

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