Abstract
Objective. To determine the trends of serum lipid levels and dyslipidemia in adults newly diagnosed with type 2 diabetes mellitus during 2003–2012 in Southwest China. Methods. Serum lipid measurements of 994 adults were obtained from 5 independent, cross-sectional studies (2003-2004, 2005-2006, 2007-2008, 2009-2010, and 2011-2012). The main outcome measures were mean serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride levels; body mass index; hemoglobin A1C level; and the percentages of patients with dyslipidemia, hypertension, coronary heart disease, and cerebrovascular disease. Results. The mean total cholesterol and low-density lipoprotein cholesterol levels increased from 4.92 ± 1.15 to 5.30 ± 1.17 mmol/L (P = 0.039) and 2.72 ± 0.83 to 3.11 ± 1.09 mmol/L (P = 0.004), respectively, and the mean HDL cholesterol level declined from 1.22 ± 0.30 to 1.06 ± 0.24 mmol/L (P < 0.001). The percentages of patients with dyslipidemia increased gradually. The incidence of coronary heart and cerebrovascular diseases increased from 8.2% to 19.1% and 6.6% to 15.3%, respectively (P < 0.05). Conclusion. Unfavorable upward trends were observed in serum lipid levels and the prevalence of dyslipidemia, coronary heart disease, and cerebrovascular disease in adults newly diagnosed with type 2 diabetes mellitus in Southwest China during 2003–2012.
Highlights
In recent years, owing to the rapid economic development and changes in lifestyle, the number of patients with diabetes mellitus in China has increased dramatically
Numerous studies have shown that serum lipid levels are high in diabetes patients, data on serum lipid and lipoprotein levels in patients newly diagnosed with type 2 diabetes mellitus are scarce, especially in Chongqing, a midlevel developed city in Southwest China with living conditions representative of the majority of Chinese cities and a fitting representative of the general Chinese population
We found that both the total cholesterol (TC) levels and the percentage of patients with hypercholesterolemia increased gradually, and the same trend was observed for LDL cholesterol
Summary
In recent years, owing to the rapid economic development and changes in lifestyle, the number of patients with diabetes mellitus in China has increased dramatically. Among the patients with type 2 diabetes mellitus, cardiovascular disease is the most important cause of mortality and morbidity. It is difficult to diagnose and manage, and many clinicians ignore the importance of dyslipidemia in patients with diabetes. Numerous studies have shown that serum lipid levels are high in diabetes patients, data on serum lipid and lipoprotein levels in patients newly diagnosed with type 2 diabetes mellitus are scarce, especially in Chongqing, a midlevel developed city in Southwest China with living conditions representative of the majority of Chinese cities and a fitting representative of the general Chinese population
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