Trends in the Design of Intensity-Based Optical Fiber Biosensors (2010-2020).

Nerea De Acha,Ignacio R Matías,Abián B Socorro-Leránoz,César Elosúa

doi:10.3390/bios11060197

Nerea De Acha, Ignacio R Matías + Show 2 more

Open Access

https://doi.org/10.3390/bios11060197

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Abstract

There exists an increasing interest in monitoring low concentrations of biochemical species, as they allow the early-stage detection of illnesses or the monitoring of the environment quality. Thus, both companies and research groups are focused on the development of accurate, fast and highly sensitive biosensors. Optical fiber sensors have been widely employed for these purposes because they provide several advantages for their use in point-of-care and real-time applications. In particular, this review is focused on optical fiber biosensors based on luminescence and absorption. Apart from the key parameters that determine the performance of a sensor (limit of detection, sensibility, cross-sensibility, etc.), other features are analyzed, such as the optical fiber dimensions, the sensing set ups and the fiber functionalization. The aim of this review is to have a comprehensive insight of the different aspects that must be taken into account when working with this kind of sensors.

Highlights

This comprehensive review has analyzed the main luminescence and absorptionbased optical fiber biosensors that the scientific community has published in the literature during the last decade
The main objective has been to discover what kind of optical fibers and configuration set-ups are normally utilized, the main parameters to consider when fabricating and characterizing them and what applications they are used for
The following lines summarize the main conclusions that arose and the trends in the state of the art when designing this kind of biosensors

Summary

Introduction

Based Optical Fiber BiosensorsIn recent years, great efforts have been made to enhance our quality of life. Most of them are devoted to the treatment or curing of severe diseases [1], their prevention and early detection are gaining interest among scientists [2] and companies [3], and governments [4] These goals involve, for instance, the real-time monitoring of water and air quality [5] or the rapid detection of biomarkers related to illnesses [6]. One of the most studied during the last decades is that based on optical fiber It offers several advantages such as biocompatibility [7], the possibility of in-situ monitoring [8] and the possibility of multiparameter sensing [9], among others. These features facilitate its utilization in pointof-care and/or real-time applications

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Conclusion