Abstract
Single nucleotide polymorphisms (SNPs) are genetic markers that are usually diallelic. In recent years they have gained in popularity because of their high prevalence in the genome and their amenability to automated analyses. Before 1996 linkage analysis had been the mainstay of early-stage discovery of genes that predispose to disease, but in 1996 Risch and Merikangas highlighted the potential of an older technique, association analysis, for detecting alleles that produce modest phenotypic effect. 1 Risch N Merikangas K The future of genetic studies of complex human diseases. Science. 1996; 273: 1516-1517 Crossref PubMed Scopus (4272) Google Scholar Now, 5 years later, R U Uhl and colleagues 2 Uhl RU Liu QR Walther D Hess J Naiman D Polysubstance abuse-vulnerability genes: genome scans for association using 1004 subjects and 1494 single nucleotide polymorphisms. Am J Hum Genet. 2001; 69: 1290-1300 Summary Full Text Full Text PDF PubMed Scopus (222) Google Scholar have completed a genome-wide SNP association study. They genotyped more than 1000 people for almost 1500 SNPs, to identify genetic loci associated with vulnerability to polysubstance abuse.
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