Abstract
INTRODUCTION: We analyzed the trends in primary multidrug-resistant tuberculosis (MDR-TB).METHODS: We performed a time series analysis of primary MDR-TB cases reported in the State of Rio de Janeiro (RJ) during 2000-2019. The annual percent change and the average annual percentage change (AAPC) were computed using joinpoint regression analysis. RESULTS: The percentage of cases increased from 7.69% in 2000 to 38.42% in 2018. We observed an upward trend during this period (AAPC = 9.4; 95% confidence interval 1.4-18.0, p < 0.001). CONCLUSIONS: The trend indicates the increasing occurrence of MDR-TB transmission sources in RJ during 2000-2019.
Highlights
We analyzed the trends in primary multidrug-resistant tuberculosis (MDR-TB)
We performed a time series analysis of primary MDR-TB cases reported in the State of Rio de Janeiro (RJ) during 2000-2019
We observed an upward trend during this period (AAPC = 9.4; 95% confidence interval 1.4-18.0, p < 0.001)
Summary
Abstract Introduction: We analyzed the trends in primary multidrug-resistant tuberculosis (MDR-TB). Methods: We performed a time series analysis of primary MDR-TB cases reported in the State of Rio de Janeiro (RJ) during 2000-2019. The leading hypothesis for the increase in resistance cases is related to treatment failure (acquired drug resistance), the large gap in diagnosis and treatment increases the probability of the primary transmission of MDR-TB6.
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