Trends in modifiable behaviorally related cancers: Who is affected the most?

Abstract

e13531 Background: To examine trends in modifiable behaviorally related cancers among racial groups in the United States. Methods: Data were obtained from the United States Cancer Statistics (USCS) database for all cancers diagnosed between 2001 and 2017. Alcohol-associated cancers, HPV-associated, obesity-associated, physical inactivity-associated, and tobacco-associated were defined using ICD-O-3 site codes. SEER*Stat 8.3.8 and Joinpoint regression program 4.8.0.1 were used to calculate the trends of associated cancers expressed per 100,000. Results: In women, the incidence of all cancers has decreased significantly or remain unchanged for all racial groups in 2017, with the exception of an increase of HPV related cancers in white women (APC = 0.77%, p < 0.001), obesity related cancers in Hispanic women (APC = 0.46%, p < 0.001), and postmenopausal breast cancer in Black and Asian women (APC 0.78%, 1.06%, p < 0.001). The incidence of alcohol, tobacco, obesity, and physical inactivity associated cancer decreased significantly in men for all racial groups in 2017. HPV related cancers increased annually by 3.13% (p < 0.001) in White men and 0.90% in Asian men (p = 0.022). The highest decrease in modifiable factors associated with cancers was in physical inactivity related cancers in black men from the west (APC = -3.79, p < 0.001). The intersection of black race and U.S. region had the highest decreases in all cancers except obesity-related cancers where the intersection of Asian race and Midwest region had the highest decrease. Conclusions: In women, most modifiable factors associated with cancer are decreasing except in obesity related cancers and physical inactivity/obesity related postmenopausal breast cancer. In men, these rates of cancer are decreasing for all racial groups except HPV related cancers in White and Asian men.