Trends in mastectomy rates over time in elderly women with stage I, hormone-sensitive breast cancer: A SEER-based study.

Abstract

1063Background: Randomized trials and registry data established that breast conservation with lumpectomy (Lump) and breast radiotherapy (RT) yields equivalent cancer outcomes to mastectomy (Mast) for women with early stage breast cancer (BC). Clinical trial data since 2004 increasingly supports that Lump alone compared to Lump+breast RT results in equivalent survival and acceptable cancer control in women ≥ 70 years old with stage I (T1N0) hormone-sensitive (HS) BC on endocrine therapy. Since Lump alone represents sufficient treatment for elderly women with stage I HS BC we hypothesize that Mast rates have decreased in this subgroup. Methods: We used the Surveillance Epidemiology and End Results (SEER) registry data to conduct this study. We included women ≥ 70 years old with T1N0 HS BC classified as ER+ or PR+ from 2000-2012. We compared rates of Mast and Lump (+/-RT) in women diagnosed before 2004 to those diagnosed from 2005-2012. We also examined Lump and Mast rates by race: White, Black, and Asian-Pa...