Abstract
Lung cancer remains one the most common cancers in Europe and ranks first in terms of cancer mortality in both sexes. Incidence rates vary by region and depend above all on the prevalence of tobacco consumption. In this study we describe recent trends in lung cancer incidence by sex, age and histological type in Catalonia and project changes according to histology by 2025. Bayesian age-period-cohort models were used to predict trends in lung cancer incidence according to histological type from 2012 to 2025, using data from the population-based Catalan cancer registries. Data suggest a decrease in the absolute number of new cases in men under the age of 70 years and an increase in women aged 60 years or older. Adenocarcinoma was the most common type in both sexes, while squamous cell carcinoma and small cell carcinoma were decreasing significantly among men. In both sexes, the incident cases increased by 16% for patients over 70 years. Increases in adenocarcinoma and rising incidence in elderly patients suggest the need to prioritize strategies based on multidisciplinary teams, which should include geriatric specialists.
Highlights
Lung cancer remains one of the most common incident cancers in Europe, ranking first in terms of cancer mortality in both sexes
Targeted systemic therapies for lung cancer are increasingly being developed for different histologies, which are usually characterized by specific biomarkers[9,10]
In light of the changes in histology by sex and the resulting implications for evaluating treatment needs, this study aims to assess incidence trends in lung cancer according to age, sex, and histology, and to make projections on incidence in Catalonia to 2025
Summary
Lung cancer remains one of the most common incident cancers in Europe, ranking first in terms of cancer mortality in both sexes. In that analysis, Spain showed a distinct pattern, with the squamous type still dominant among men, similar to the pattern in France. These divergent trends could have therapeutic implications due to the differential treatment approaches by histological type and location[8]. Targeted systemic therapies for lung cancer are increasingly being developed for different histologies, which are usually characterized by specific biomarkers[9,10] These may have a predictive effect on which treatment strategy is followed[9,10]. In light of the changes in histology by sex and the resulting implications for evaluating treatment needs, this study aims to assess incidence trends in lung cancer according to age, sex, and histology, and to make projections on incidence in Catalonia to 2025
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