Trends in Incidences, Prevalence Cases, and the Disability-Adjusted Life-Years of Bipolar Disorder in China, 1990-2019

Abstract

Objectives: Studies on Chinese bipolar disorders are incomplete and lagged to date. Methods: We used the join point regression program to assess the incidence, prevalence, and disease burdens of Chinese bipolar disorders, based on the Global Burden of Disease exchange database. Results: We observed the increasing trends in the incidence and prevalence of Chinese bipolar disorder in 1990- 2019, with increases of 22.26% in incidence number, 40.73% in prevalence number, and 17.12% in prevalence rate; wherein females had a higher prevalence rate in 1990-2019 and a higher incidence rate in 1990-2013 but a reversed trend thereafter; the Disability-Adjusted Life Years (DALY) increased by 78% for number and 15.81% for rate, respectively; those aged 30-34 shared the highest DALY number in 2019 (73,194; 95% UI (Uncertainty Interval): 43,128-113,623); the DALY-related Annual Percentage Change (APC) in 1990-2019 was 1.21% (P=0.000). Conclusion: Bipolar disorder is being developed into an immense societal burden in China. An essential intervention strategy should be formulated earlier to better identify and treat bipolar disorders so that we can reduce negative outcomes and DALY in China.