Abstract
ObjectivesThe incidence of ischemic stroke has increased and that of hemorrhagic stroke has decreased in urban China; however, the trends in rural areas are unknown. We aimed to explore the secular trends in incidence and transition of stroke subtypes among rural Chinese.MethodsThis was a population-based stroke surveillance through the Tianjin Brain Study. A total of 14,538 residents in a township of Ji County in Tianjin, China participated in the study since 1985. We investigated the age-standardized stroke incidence (sex-specific, type-specific, and age-specific), the annual proportion of change in the incidence of stroke, and the proportion of intracerebral hemorrhage in the periods 1992–1998, 1999–2005, and 2006–2012, because the neuroimaging technique was available since 1992 in this area.ResultsThe age-standardized incidence per 100,000 person-years increased significantly for both intracerebral hemorrhage (37.8 in 1992–1998, 46.5 in 1999–2005, and 76.5 in 2006–2012) and ischemic stroke (83.9 in 1992–1998, 135.3 in 1999–2005, and 238.0 in 2006–2012). The age-standardized incidence of first-ever stroke increased annually by 4.9% for intracerebral hemorrhage and by 7.3% for ischemic stroke. The greatest increase was observed in men aged 45–64 years for both stroke types (P < 0.001). The proportion of intracerebral hemorrhage was stable overall, increased among men aged 45–64 years, and decreased among men aged ≥65 years. The average age of intracerebral hemorrhage in men reduced by 7.5 years from 1992 to 2012.ConclusionThe age-standardized incidence of main stroke subtypes increased significantly in rural China over the past 21 years; the overall proportion of intracerebral hemorrhage was stable, but the incidence increased significantly among middle-aged men. These findings imply that it is crucial to control stroke risk factors in middle-aged men for stroke prevention in future decades.
Highlights
Stroke is the leading cause of death and disability in both developed and developing countries worldwide [1,2,3]
The greatest increase was observed in men aged 45–64 years for both stroke types (P < 0.001)
The average age of intracerebral hemorrhage in men reduced by 7.5 years from 1992 to 2012
Summary
Stroke is the leading cause of death and disability in both developed and developing countries worldwide [1,2,3]. In China, stroke is the leading cause of death in rural areas but is the third most common cause of death in urban areas [10]. A study from an urban population in Beijing from 1984 to 2004 indicated that the incidence of ICH decreased while that of IS increased annually [11]. There are currently no reports describing the long-term trends in the incidence of stroke subtypes among rural residents in China. The previous studies have indicated that the incidence of first-ever stroke in rural Chinese increased rapidly in past twenty years [12,13]. The transition of stroke subtypes following increased incidence of stroke is unknown in rural China; the prevention of stroke in rural China is crucial to reduce stroke incidence in China
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