TRENDS IN HOSPITALIZATIONS RELATED TO ANAPHYLAXIS, ANGIOEDEMA AND URTICARIA IN THE UNITED STATES (2001-2014)

Abstract

Introduction There are limited data for prevalence of allergic disorders over time. Recent studies have noted marked increase in prevalence of allergic conditions over different parts of the world. We sought to examine time trends in the prevalence of anaphylaxis, angioedema and urticaria in the US. Methods Using the largest inpatient National Inpatient Sample data in US from 2001-2014, adults admitted with a primary diagnosis of anaphylaxis, angioedema, urticaria were identified based on International Classification of disease-9 codes. Yearly distribution of hospital admissions was stratified per different age groups. STATA version 13.0 (College Station, TX), MS-Excel 2016 and Joinpoint Regression Program version 4.5.0.1 were used to determine yearly trend of hospitalizations related to anaphylaxis, angioedema and urticaria. Results While an increasing trend in the rate of hospitalizations was seen for angioedema (annual percentage change [APC] 4.48), a decreasing trend (APC -2.19) was observed for urticaria-related hospitalizations. Overall anaphylaxis-related hospitalizations were noted to be stable, but a significant increasing trend was observed among age group 5-14 years (APC 4.19), mostly due to the subgroup of food-related hospitalizations (APC 5.86). Angioedema-related hospitalizations were found to be highest among the 35-64 years age group (APC 5.38). Trends in hospitalizations related to anaphylaxis, angioedema and urticaria in US (2001–2014) Conclusions An increasing trend of hospitalizations has been observed for allergic conditions, with varying age-distribution according to the nature of eliciting agent and susceptibility of different age groups. While angioedema has been observed as an increasing problem in older population, food-induced anaphylaxis is a growing concern in the younger population. There are limited data for prevalence of allergic disorders over time. Recent studies have noted marked increase in prevalence of allergic conditions over different parts of the world. We sought to examine time trends in the prevalence of anaphylaxis, angioedema and urticaria in the US. Using the largest inpatient National Inpatient Sample data in US from 2001-2014, adults admitted with a primary diagnosis of anaphylaxis, angioedema, urticaria were identified based on International Classification of disease-9 codes. Yearly distribution of hospital admissions was stratified per different age groups. STATA version 13.0 (College Station, TX), MS-Excel 2016 and Joinpoint Regression Program version 4.5.0.1 were used to determine yearly trend of hospitalizations related to anaphylaxis, angioedema and urticaria. While an increasing trend in the rate of hospitalizations was seen for angioedema (annual percentage change [APC] 4.48), a decreasing trend (APC -2.19) was observed for urticaria-related hospitalizations. Overall anaphylaxis-related hospitalizations were noted to be stable, but a significant increasing trend was observed among age group 5-14 years (APC 4.19), mostly due to the subgroup of food-related hospitalizations (APC 5.86). Angioedema-related hospitalizations were found to be highest among the 35-64 years age group (APC 5.38). Trends in hospitalizations related to anaphylaxis, angioedema and urticaria in US (2001–2014) An increasing trend of hospitalizations has been observed for allergic conditions, with varying age-distribution according to the nature of eliciting agent and susceptibility of different age groups. While angioedema has been observed as an increasing problem in older population, food-induced anaphylaxis is a growing concern in the younger population.