Trends in fluoroquinolone resistance in Campylobacter.

Emma L Sproston,Samuel K Sheppard,Helen M L Wimalarathna

doi:10.1099/mgen.0.000198

Emma L Sproston, Samuel K Sheppard + Show 1 more

Open Access

https://doi.org/10.1099/mgen.0.000198

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Abstract

Members of the genus Campylobacter remain a leading cause of bacterial gastroenteritis worldwide. Infection is usually self-limiting but in severe cases may require antibiotic treatment. In a recent statement by the World Health Organization (WHO) Campylobacter was named as one of the 12 bacteria that pose the greatest threat to human health because they are resistant to antibiotics. In this mini review we describe recent trends in fluoroquinolone (FQ) (particularly ciprofloxacin) resistance in strains of members of the genus Campylobacter isolated from livestock and clinical samples from several countries. Using evidence from phenotyping surveys and putative resistance prediction from DNA sequence data, we discuss the acquisition and spread of FQ resistance and the role of horizontal gene transfer and describe trends in FQ-resistance in samples from livestock and clinical cases. This review emphasises that FQ resistance remains common among isolates of members of the genus Campylobacter from various sources.

Highlights

This report summarizes the major findings of the National Antimicrobial Resistance Monitoring System (NARMS) for calendar year 2014, including the most important resistance findings for Salmonella and Campylobacter, Escherichia coli (E. coli) and Enterococcus.Salmonella and Campylobacter are the leading bacterial causes of foodborne illness in the United States
Among Salmonella isolates tested by NARMS in 2014, 9% (31/344) from PR/HACCP cattle and 23% (3/13) from retail ground beef were serotype Dublin
We have previously reported two cases of infection by Salmonella that contained the carbapenemase genes [ blaKPC [7] in 1998 and blaNDM-1 in 2011 [8], we have not found any additional carbapenemase-producing Salmonella or E. coli in human, retail food, or cecal samples collected for routine NARMS surveillance

Summary

Introduction

This report summarizes the major findings of the National Antimicrobial Resistance Monitoring System (NARMS) for calendar year 2014, including the most important resistance findings for Salmonella and Campylobacter, Escherichia coli (E. coli) and Enterococcus.Salmonella and Campylobacter are the leading bacterial causes of foodborne illness in the United States. Ceftriaxone resistance in Salmonella isolates recovered from cattle PR/HACCP sampling (Figure 6) declined to 7.5% in 2014, the lowest level since 1999. It is among the most common Salmonella serotypes isolated from PR/HACCP cattle and retail ground beef sampling.

Results

Conclusion