Abstract
Objectives: To discuss the scientific rationale for the use of monoclonal antibodies in cancer treatment and distinguish the unique characteristics of selected monoclonal antibodies. Data Sources: Published scientific papers, abstracts, review articles, and book chapters. Conclusion: The continued discovery of intrinsic antigens/epitopes specific to malignant cells and the science of immune cell activation demonstrates the durability of monoclonal antibodies as mainstream immunotherapy. Implications for Nursing Practice: With the success of monoclonal antibodies used in clinical practice, oncology nurses need to continue to increase their knowledge and competency. Monoclonal antibodies target tumor-associated antigens in both solid and hematologic tumors. It is imperative that nurses be familiar with specific aspects of each antibody infusion they administer.
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